The Cerebellar Vermis as the Cortex of the Protoself
Protoself
PPT Slide
The Cerebellar Symphony:Olivocerebellar-Fastigial Nuc. feedback oscillations
Autonomic, vasomotor and EEG synchronization effects of fastigial stimulation -Elevation of arterial pressure -Releases vasoactive hormones -Elevates rCBF independent of rCGU
Cerebellar Nuclear neurons that are activated by collaterals of afferent axons (such as branches of spinocerebellar fibers) may communicate directly with hypothalamic nuclei via cerebelohypothalamic projections; such circuits may be excitatory and/or inhibitory. Fig.3 from Haines, D.E. et al. Int. Rev. Neur. 41:83-104, 1997
The hypothalamus, in turn, may directly modulate the activity of cerebellar nuclear or cerebellar cortical neurons via hypothalamocerebellar projections Fig.2 from Haines, D.E. et al. Int. Rev. Neur. 41:83-104, 1997
Theory of the Emotional-Dream Motor System: Bilateral CV-PB-PAG-EA networks. -REM sleep allows the Levy stable fractal fluctuations, similar to those present in the fetal state, to self organize out of CV-PB-PAG-EA cellular activity supplying synaptic and network plasticity in limbic regions.
Role of the Emotional-Dream Motor System in Psychopathology. -Abuse trauma, by inducing cerebellar disorder, results in the development of psychopathological interhemispheric dynamics and disturbed sleep structure ( Vermis coordinates sleep architecture). -Therapeutic techniques such EMDR, Ibogaine, (others?) reintroduce plasticity into the bihemispheric cerebellar-protoself system. -
Figs 1&3 from Middleton & Strict, Science 266:451-458, 1994
Figs 4 from Middleton & Strict, Science 266:451-458, 1994
The corticopontine projections from association areas favor peripheral vision Areas concerned with visual motion (the ‘where’ pathway) and the peripheral visual field have projections to pons (the first stage in the feedforward limb of the cerebrocerebellar circuit), whereas cortical regions concerned with visual feature discrimination (the ‘what’ pathway) and the central visual field do not. (From Schmahmann (1998) TICS, 2(9):362-371)
With 5x1010 neurons the cerebellum is the most sophisticated inhibitory GABAergic system in the brain
“Llinas et al., show that dynamic synchronization of ever changing subgroups of inferior olivary neurons may organize cerebellar activity during the performance of well-learned movements (& emotional responses?), thereby making the IO a conductor of the symphony of cerebellar neuronal activity.” McCormic, Nature 374:412-413 (1995).
Evolutionary changes in the cerebellar output nuclie
Ibogaine changes the score: Ibogaine-induced vermal plasticity mediates its anti-addictive properties
Email: carl_anderson@hms.harvard.edu
Home Page: http://remfractal.mclean.org:8080/
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